Pep Guardiola and José Mourinho will meet again after the two Manchester clubs were paired together in the fourth round draw for the EFL Cup on Wednesday night.
Cup holders City, who won 2-1 at Old Trafford in the Premier League earlier this month, will return there in the last week of October after their 2-1 win at Swansea. Mourinho’s United wobbled before defeating League One Northampton Town 3-1.
The Manchester derby was not the only heavyweight tie, with Liverpool and Tottenham Hotspur also set to do battle for a place in the quarter-finals.
Meanwhile, there will be a London derby between West Ham United and Chelsea, who won a dramatic third-round tie against Leicester in extra-time on Tuesday.
Norwich’s reward for beating Everton at Goodison Park is a trip to Elland Road to face Leeds while Preston, who took the Premier League scalp of Bournemouth, will travel to Newcastle.
Arsenal host Reading while Hull travel to the south west to face Bristol City and there is an all-Premier League clash between Southampton and Sunderland.
Full fourth round draw
West Ham United v Chelsea
Manchester United v Manchester City
Arsenal v Reading
Liverpool v Tottenham
Bristol City v Hull
Leeds United v Norwich City
Newcastle United v Preston NE
Southampton v Sunderland
Ties to be played week commencing 24 October